Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoglycerol is a high-purity synthetic phospholipid, specifically a phosphatidylglycerol (PG) derivative with two oleoyl chains. This compound is a critical building block in the formulation of advanced lipid-based delivery systems, offering superior biocompatibility and membrane-fusion properties. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation liposomal drug carriers, mRNA vaccines, and diagnostic agents.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key excipient for constructing stable, anionic liposomal bilayers used in drug delivery and vaccine platforms.
• mRNA Vaccine & Therapeutic Development: Used as a component in lipid nanoparticle (LNP) systems to encapsulate and protect nucleic acids for cellular delivery.
• Model Membrane Systems: Employed in biophysical studies to create synthetic membranes that mimic specific biological conditions or charge characteristics.
• Pulmonary Surfactant Research: Serves as a synthetic analog in studies related to lung surfactant function and replacement therapies.
• Diagnostic Agent Carrier: Utilized in the development of contrast agents for medical imaging, such as ultrasound or MRI.
• Cosmetic & Dermal Delivery Systems: Incorporated into nanocarriers for the enhanced skin penetration and stabilization of active cosmetic ingredients.

Basic Information

Item	Details
Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoglycerol
CAS No.	66322-31-4
Molecular Formula	C42H79O10P
Molecular Weight	775.05 g/mol
Synonyms	DOPG; 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol); 1,2-Dioleoylphosphatidylglycerol; PG(18:1/18:1); (2,3-Bis(9Z-octadecenoyloxy)propyl)[(2R)-2,3-dihydroxypropoxy]phosphinate; Sodium Salt of DOPG (common form); Dioleoyl Phosphatidylglycerol
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoglycerol is manufactured under strict quality management systems. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as assay, fatty acid profile, and impurity limits. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to minimize condensation. Once opened, purge the container with inert gas and reseal immediately.

Specification

Item	Specification
Appearance	White to off-white waxy solid or lyophilized powder
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
1,2-Dioleoyl Isomer Content	≥ 95.0%
Lyso-Impurity (HPLC)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%
Peroxide Value	≤ 3.0 meq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.