Description

3-tert-Butylcyclobutanecarboxylic Acid is a specialized organic acid featuring a cyclobutane ring substituted with a bulky tert-butyl group, offering unique steric and electronic properties. This compound serves as a valuable high-purity building block and intermediate for advanced chemical synthesis, where its constrained ring structure is critical for modulating molecular conformation and reactivity. It is primarily utilized by pharmaceutical researchers and agrochemical developers in the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the tert-butylcyclobutane moiety can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis, leveraging its rigid backbone for stereocontrol.
• Material Science Research: Intermediate for the synthesis of specialty monomers and polymers, contributing to materials with tailored thermal and mechanical properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying enzyme function and cellular processes.
• Flavor & Fragrance Chemistry: Potential intermediate for creating complex aroma chemicals with unique olfactory characteristics.

Basic Information

Product Name	3-tert-Butylcyclobutanecarboxylic Acid
CAS No.	66016-27-1
Molecular Formula	C9H16O2
Molecular Weight	156.22 g/mol
Synonyms	3-(1,1-Dimethylethyl)cyclobutanecarboxylic Acid; 3-tert-Butylcyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 3-(1,1-dimethylethyl)-; 3-(tert-Butyl)cyclobutanecarboxylic acid; 3-tert-Butyl-1-cyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 3-tert-Butylcyclobutanecarboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, ensure containers are made of compatible materials and are properly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.