Description

Sodium Acetate-18O2 CAS NO 66012-98-4 is a stable isotope-labeled analog of sodium acetate, where the oxygen atoms are enriched with the non-radioactive isotope Oxygen-18. This compound is a critical tool in advanced research, enabling precise metabolic pathway tracing and mechanistic studies. It is essential for scientists in pharmaceutical development, metabolic research, and analytical chemistry who require high-purity isotopic tracers for mass spectrometry and NMR applications.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism in cells, tissues, or whole organisms using techniques like GC-MS or LC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard for the accurate quantification of acetate and related metabolites in bioanalytical assays.
• Biochemical Pathway Elucidation: Enables the detailed mapping of acetyl-CoA utilization in biosynthesis and energy production pathways.
• Proteomics and Post-Translational Modification Studies: Investigates protein acetylation dynamics by tracing the incorporation of the labeled acetyl group.
• Environmental and Microbial Ecology: Tracks acetate assimilation in complex microbial communities to understand carbon cycling.
• NMR Spectroscopy: Provides a distinct signal for Oxygen-18, facilitating structural and dynamic studies of molecules incorporating the labeled acetate.

Basic Information

Product Name	Sodium Acetate-18O2
CAS No.	66012-98-4
Molecular Formula	C13H318O2Na or CH3C(18O)2Na
Molecular Weight	~85.03 g/mol (for 13C1, 18O2 labeled)
Synonyms	Acetic-18O2 Acid Sodium Salt; Sodium [18O2]Acetate; [18O2]-Sodium Acetate; Isotopic Sodium Acetate (O-18); Sodium Acetate (O-18 Labeled); CH313C18O2Na; Sodium Salt of Acetic-18O2 Acid
EINECS	Contact for details

Quality Control

Every batch of Sodium Acetate-18O2 is produced and analyzed under strict quality systems to ensure isotopic and chemical purity for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (Atom % 18O), chemical purity, and identity confirmation. Our quality commitment aligns with the standards expected for high-value isotopic reagents in pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term stability, consider storage under inert atmosphere or in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR / NMR)	Conforms to structure
Isotopic Enrichment (Atom % 18O)	≥ 95% (Typical 97-99%)
Chemical Purity (HPLC / Titration)	≥ 98%
Isotopic Purity (MS)	≥ 95%
pH (5% solution)	7.0 - 9.0
Water Content (KF)	≤ 2.0%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.