Description

12-Deoxyphorbol-13-Angelate is a bioactive diterpene ester belonging to the phorbol family, known for its specific biological activity profile. This compound is of significant interest in advanced biochemical and pharmacological research for its role as a reference standard and a key intermediate in synthetic studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and specialty chemical manufacturers focused on natural product chemistry, drug discovery, and signal transduction pathway analysis.

Application

• Biochemical Research: Used as a high-purity reference standard for analytical method development and validation in natural product analysis.
• Pharmacological Studies: Serves as a key intermediate or tool compound in the investigation of protein kinase C (PKC) modulation and related cellular signaling pathways.
• Pharmaceutical Development: Employed as a building block or precursor in the synthesis of novel therapeutic agents and probes for medicinal chemistry programs.
• Academic Research: Utilized in university and institutional labs for studies involving diterpene chemistry, structure-activity relationships (SAR), and natural product biosynthesis.
• Quality Control: Acts as a certified reference material (CRM) for the quality assurance and impurity profiling of related natural extracts or synthetic batches.

Basic Information

Product Name	12-Deoxyphorbol-13-Angelate
CAS No.	65700-60-9
Molecular Formula	C27H36O6
Molecular Weight	456.58 g/mol
Synonyms	12-Deoxyphorbol 13-angelate; 12-Deoxyphorbol-13-angelic acid ester; 12-DPA; 4,9,12,13-Tetrahydroxy-1,6-tigliadien-3-one 13-angelate; Deoxyphorbol angelate; NSC 328426; Ingenol-type diterpene ester
EINECS	Contact for details

Quality Control

Our 12-Deoxyphorbol-13-Angelate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.