Description

1α-Hydroxy-5,6-trans-Vitamin D3 is a synthetic analog of vitamin D, specifically engineered to modulate calcium and phosphate metabolism. This compound is valued for its potent biological activity and serves as a critical intermediate in the research and development of therapeutic agents targeting bone and mineral disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on endocrinology and metabolic diseases.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of advanced vitamin D analogs and calcitriol derivatives for therapeutic use.
• Biochemical Research: Used as a reference standard and probe in studies investigating vitamin D receptor (VDR) activation, gene regulation, and calcium homeostasis pathways.
• API Development: Serves in the development and scale-up of Active Pharmaceutical Ingredients (APIs) for treatments of osteoporosis, renal osteodystrophy, and hypoparathyroidism.
• Metabolic Studies: Employed in preclinical and clinical research to understand the metabolism and pharmacokinetics of vitamin D-related compounds.
• Nutraceutical R&D: Investigated for potential applications in advanced dietary supplements targeting bone health, though primarily for research purposes.

Basic Information

Product Name	1α-Hydroxy-5,6-trans-Vitamin D3
CAS No.	65445-15-0
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	1α-Hydroxy-5,6-trans-cholecalciferol; 1α-OH-5,6-trans-D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-1α,3β-diol; 1α-Hydroxyprevitamin D3; Alfacalcidol precursor; 1α-Hydroxy-5,6-trans Vitamin D3
EINECS	Contact for details

Quality Control

Our 1α-Hydroxy-5,6-trans-Vitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets rigorous research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.