Description

p-Nicorandil is a potent vasodilator and cardioprotective agent belonging to the nicotinamide nitrate class of compounds. This high-purity pharmaceutical intermediate is critical for the development and manufacturing of advanced cardiovascular therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and production facilities focused on creating treatments for angina pectoris and ischemic heart disease. Our supply ensures the stringent quality and consistency required for critical pharmaceutical synthesis.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of anti-anginal medications.
• Cardiovascular Drug Synthesis: Key intermediate for the production of drugs targeting coronary artery disease and chronic heart failure.
• Pharmacological Research: Standard compound for studying potassium channel activation and nitrate-mediated vasodilation mechanisms.
• Preclinical & Clinical Development: Used in the development and scale-up of new cardioprotective drug candidates.
• Reference Standard: Serves as an analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.

Basic Information

Product Name	p-Nicorandil
CAS No.	65141-47-1
Molecular Formula	C8H9N3O4
Molecular Weight	211.17 g/mol
Synonyms	Nicorandil; 2-Nicotinamidoethyl Nitrate; N-(2-Hydroxyethyl)nicotinamide Nitrate; SG-75; Sigmart; Ikorel; N-(2-Nitroxyethyl)nicotinamide; N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
EINECS	Contact for details

Quality Control

Our p-Nicorandil is manufactured under strict quality management systems to meet the exacting standards of the pharmaceutical industry. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant pharmacopeial guidelines and support our clients' regulatory submissions with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.