Description

Nicorandil is a potent vasodilator and antianginal agent belonging to the nitrate-potassium channel opener class of pharmaceuticals. Its primary value lies in its dual mechanism of action, which offers effective management of chronic stable angina pectoris, particularly in patients who are refractory to conventional nitrate therapy. This compound is essential for pharmaceutical manufacturers and research institutions focused on cardiovascular drug development and production. The global demand for high-purity Nicorandil CAS NO 65141-46-0 is driven by its critical role in advanced cardiac treatment formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of finished dosage forms (tablets) for the treatment of angina pectoris.
• Cardiovascular Research: A key reference standard and investigational compound in preclinical and clinical studies exploring coronary vasodilation and cardioprotection.
• Generic Drug Production: Sourcing of API for the formulation of bioequivalent generic versions of branded antianginal medications.
• Analytical Standard: Used as a high-purity standard in quality control laboratories for HPLC, UV, and other chromatographic assay methods.
• Mechanistic Studies: Employed in pharmacological research to study the effects of potassium channel activation and nitrate donation on vascular smooth muscle.
• Formulation Development: Serves as the core active component in the R&D of new drug delivery systems and combination therapies for ischemic heart disease.

Basic Information

Product Name	Nicorandil
CAS No.	65141-46-0
Molecular Formula	C8H9N3O4
Molecular Weight	211.18 g/mol
Synonyms	2-Nicotinamidoethyl nitrate; N-(2-Hydroxyethyl)nicotinamide nitrate ester; SG-75; Sigmart; Perisalol; Ikorel; N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide; 3-Pyridinecarboxamide, N-[2-(nitrooxy)ethyl]-
EINECS	265-560-8

Quality Control

Our Nicorandil is manufactured and tested to meet stringent pharmacopeial standards, ensuring consistency and reliability for critical pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to a robust quality management system aligned with cGMP principles, providing our global partners with the supply chain assurance required for API integration.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.