Description

n-[2-(Nitrooxy)Ethyl]Nicotinamide Monohydrochloride is a specialized organic nitrate ester derivative of nicotinamide. This compound is of significant interest in pharmaceutical research and development, particularly as a nitric oxide (NO) donor prodrug. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel cardiovascular and metabolic therapies, where controlled nitric oxide release is a key mechanism of action.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nitric oxide-donating drug candidates.
• Cardiovascular Research: Used in preclinical studies to investigate vasodilation, blood pressure regulation, and anti-ischemic effects.
• Metabolic Disorder Research: Applied in research models for studying conditions like diabetes and metabolic syndrome, where NO signaling plays a role.
• Biochemical Tool Compound: Acts as a controlled NO-releasing agent in cell culture and enzymatic studies to elucidate biological pathways.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	n-[2-(Nitrooxy)Ethyl]Nicotinamide Monohydrochloride
CAS No.	65141-45-9
Molecular Formula	C9H12N4O5 • HCl
Molecular Weight	304.68 g/mol
Synonyms	Nicorandil Impurity; 2-[(Nitrooxy)ethyl]-3-pyridinecarboxamide Hydrochloride; N-(2-Nitrooxyethyl)nicotinamide Hydrochloride; N-(2-Nitroxyethyl)nicotinamide HCl; 3-Pyridinecarboxamide, N-[2-(nitrooxy)ethyl]-, monohydrochloride; Nicotinamide, N-[2-(nitrooxy)ethyl]-, monohydrochloride; CAS 65141-45-9
EINECS	Contact for details

Quality Control

Our n-[2-(Nitrooxy)Ethyl]Nicotinamide Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom synthesis to meet specific purity or packaging requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.