Description

(S)-3-tert-Butyl-2,5-Piperazinedione CAS NO 65050-07-9 is a high-purity, chiral piperazinedione derivative, a key chiral building block in advanced organic synthesis. Its value lies in its rigid, sterically hindered structure which is instrumental for inducing stereoselectivity in complex molecular constructions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing novel active pharmaceutical ingredients (APIs), peptidomimetics, and asymmetric catalysts.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of stereochemically complex drug candidates, including protease inhibitors and other biologically active molecules.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for developing novel chiral ligands used in metal-catalyzed asymmetric reactions.
• Peptidomimetics Research: Used to construct constrained peptide analogs and foldamers due to its conformationally restricted diketopiperazine scaffold.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	(S)-3-tert-Butyl-2,5-Piperazinedione
CAS No.	65050-07-9
Molecular Formula	C8H14N2O2
Molecular Weight	170.21 g/mol
Synonyms	(3S)-3-(1,1-Dimethylethyl)-2,5-piperazinedione; (S)-3-tert-Butylpiperazine-2,5-dione; (S)-3-tert-Butyl-2,5-diketopiperazine; (S)-3-tert-Butyl-DKP; (S)-3-tert-Butyl-2,5-piperazinedione; (S)-3-(tert-Butyl)-2,5-piperazinedione; (S)-3-t-Butyl-2,5-piperazinedione
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our chiral intermediates. Every batch of (S)-3-tert-Butyl-2,5-Piperazinedione is characterized and tested to ensure identity, purity, and enantiomeric excess meet exacting standards. A comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity (HPLC), and related substances is provided with each shipment. Our quality system supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.