Description

(3As)-3Aβ,4,6,7,8,8A,9,9Aβ-Octahydro-9α-Acetyloxy-5,8Aα-Dimethyl-3-Methylenenaphtho[2,3-B]Furan-2(3H)-One is a complex, high-purity sesquiterpene lactone derivative with a unique fused furanone structure. This compound is valued as a critical advanced pharmaceutical intermediate and a versatile scaffold for synthetic organic chemistry. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical and fine chemical sectors for the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates, particularly in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis due to its intricate polycyclic framework.
• Natural Product Synthesis: Acts as a synthetic analog or intermediate in the total synthesis of complex natural products with sesquiterpene skeletons.
• Biochemical Probe Development: Utilized in the design and creation of molecular probes for studying biological pathways and enzyme interactions.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production under cGMP conditions for clinical trial material.

Basic Information

Item	Details
Product Name	(3As)-3Aβ,4,6,7,8,8A,9,9Aβ-Octahydro-9α-Acetyloxy-5,8Aα-Dimethyl-3-Methylenenaphtho[2,3-B]Furan-2(3H)-One
CAS No.	64340-35-8
Molecular Formula	C19H24O4
Molecular Weight	316.39 g/mol
Synonyms	9α-Acetoxy-14,15-dinorlabda-8(17),12E-dien-13-oic acid δ-lactone; (3aS,4S,6S,7R,8R,8aR,9S,9aS)-9-(Acetyloxy)-3a,4,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one; 8,17-Epoxylabd-12-en-15,16-olide, 9-acetoxy-; A related derivative of costunolide.
EINECS	Contact for details

Quality Control

Our production of (3As)-3Aβ,4,6,7,8,8A,9,9Aβ-Octahydro-9α-Acetyloxy-5,8Aα-Dimethyl-3-Methylenenaphtho[2,3-B]Furan-2(3H)-One adheres to stringent quality systems. Each batch is characterized and tested using advanced analytical techniques (HPLC, GC, NMR) to ensure identity, purity, and consistency. We support development and commercial projects with full traceability and comprehensive Certificates of Analysis (COA). Specifications can be aligned with research-grade or cGMP requirements based on customer need.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.