Description

4-((Benzyloxy)Carbonyl)Piperazine-2-Carboxylic Acid Hydrochloride is a high-purity, protected piperazine derivative primarily used as a critical building block in pharmaceutical synthesis. This compound is essential for medicinal chemists developing novel active pharmaceutical ingredients (APIs), particularly in the areas of protease inhibitors and other small molecule therapeutics. Its primary value lies in providing a versatile, reactive scaffold for constructing complex molecular architectures with high stereochemical control. Key industries that require this material include pharmaceutical R&D, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the life sciences sector.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetic Research: Serves as a constrained, non-natural amino acid analog for constructing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Chemical Biology Probe Development: Used to create tool compounds and labeled derivatives for studying enzyme function and biological pathways.
• Custom Synthesis & Scale-Up: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom APIs under cGMP conditions.
• Library Synthesis for Drug Discovery: Enables the generation of diverse compound libraries for high-throughput screening (HTS) campaigns in early-stage drug discovery.

Basic Information

Product Name	4-((Benzyloxy)Carbonyl)Piperazine-2-Carboxylic Acid Hydrochloride
CAS No.	64172-99-2
Molecular Formula	C13H17ClN2O4
Molecular Weight	300.74 g/mol
Synonyms	1-CBZ-3-Carboxypiperazine Hydrochloride; (2S)-1-[(Benzyloxy)carbonyl]piperazine-2-carboxylic acid hydrochloride; 1-Benzyloxycarbonyl-3-carboxypiperazine HCl; 1-Cbz-piperazine-2-carboxylic acid HCl; 4-(Benzyloxycarbonyl)piperazine-2-carboxylic acid hydrochloride; 2-Piperazinecarboxylic acid, 4-[(phenylmethoxy)carbonyl]-, hydrochloride (1:1); Z-Pip(2)-OH·HCl
EINECS	Contact for details

Quality Control

Our 4-((Benzyloxy)Carbonyl)Piperazine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.