Description

(S)-Piperazine-2-Carboxylic Acid is a high-purity, non-proteinogenic amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its rigid piperazine backbone and defined stereochemistry, enabling the precise construction of complex molecular architectures with high biological relevance. This compound is essential for research and development teams in the pharmaceutical and agrochemical industries, particularly for creating novel active pharmaceutical ingredients (APIs), peptide mimetics, and chiral ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity into peptide chains, improving metabolic stability and target selectivity.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for developing novel asymmetric catalysts and auxiliaries in enantioselective synthesis.
• Agrochemical Research: Employed in the design and synthesis of new chiral herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Useful as a building block for activity-based probes and molecular tools to study enzyme function.
• Academic & Process R&D: A valuable reagent for methodological development in organic chemistry and scalable route design.

Basic Information

Product Name	(S)-Piperazine-2-Carboxylic Acid
CAS No.	64044-11-7
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	(S)-2-Piperazinecarboxylic Acid; D-Pipecolic Acid (Note: Pipecolic acid is a homologue, but often used in searches); (S)-Piperazine-2-carboxylic acid; L-Pipecolic Acid (common misnomer); (S)-Azetidine-2-carboxylic acid (related structure); 2S-Piperazinecarboxylic Acid; (2S)-Piperazine-2-carboxylic acid; (S)-Hexahydropyridazine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-Piperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.