Description

[2-(2-Methoxy-Ethoxy)-Ethoxy]-Acetyl Chloride is a specialized organic acid chloride derivative featuring a polyethylene glycol-like (PEG) spacer, making it a valuable building block for the synthesis of functionalized polymers and conjugates. This compound is critical for introducing reactive acyl chloride functionality with enhanced solubility and biocompatibility into target molecules. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, advanced materials, and specialty chemical sectors for creating drug-polymer conjugates, surface modifiers, and functional monomers.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of prodrugs and active pharmaceutical ingredients (APIs) requiring PEGylation to improve solubility, circulation time, and bioavailability.
• Polymer Functionalization: Used to introduce reactive end-groups onto polyethylene glycol (PEG) chains or other polymers for subsequent coupling with amines, alcohols, or other nucleophiles.
• Surface Modification Agent: Employed to create functional coatings on materials (e.g., silica, metals) for biomedical devices, chromatography media, or sensors by forming stable amide or ester bonds.
• Crosslinking Agent: Serves as a linker molecule in the preparation of hydrogels, polymer networks, and dendrimers due to its bifunctional reactivity.
• Bioconjugation Chemistry: Facilitates the covalent attachment of peptides, proteins, or fluorescent dyes to carrier molecules under mild conditions.
• Specialty Surfactant Synthesis: Acts as a precursor for synthesizing novel non-ionic surfactants and emulsifiers with unique properties.

Basic Information

Product Name	[2-(2-Methoxy-Ethoxy)-Ethoxy]-Acetyl Chloride
CAS No.	63881-16-3
Molecular Formula	C7H13ClO4
Molecular Weight	196.63 g/mol
Synonyms	2-[2-(2-Methoxyethoxy)ethoxy]acetyl chloride; Acetic acid, 2-[2-(2-methoxyethoxy)ethoxy]-, chloride; PEG3 methyl ether acetic acid chloride; mPEG3-acetyl chloride; 2,5,8-Trioxaundecanoyl chloride, 11-methoxy-; Triethylene glycol monomethyl ether acetic acid chloride; (2-(2-(2-Methoxyethoxy)ethoxy)acetyl chloride); 3,6,9-Trioxadecanoyl chloride, 10-methoxy-
EINECS	Contact for details

Quality Control

Our [2-(2-Methoxy-Ethoxy)-Ethoxy]-Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and titration, to ensure high purity and consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life. Due to its nature as a strong acid/organic solvent and moisture-sensitive reagent, keep the container tightly sealed and handle under dry conditions to prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.