Description

1-(2-Trifluoromethylphenyl)-Piperazine is a high-purity, specialized aromatic piperazine derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for creating compounds with targeted biological and physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of central nervous system (CNS) active compounds, including potential antidepressants, antipsychotics, and anxiolytics.
• Agrochemical Research: Used in developing novel pesticides and herbicides, leveraging the trifluoromethyl group for enhanced bioactivity and metabolic stability.
• Ligand & Catalyst Development: Serves as a versatile ligand scaffold in organometallic chemistry and catalysis for asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of advanced polymers and functional materials with specific electronic or thermal properties.
• Chemical Biology Probe: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and target identification.
• Custom Synthesis Building Block: Provides a versatile aromatic core for contract research organizations (CROs) and fine chemical manufacturers.

Basic Information

Product Name	1-(2-Trifluoromethylphenyl)-Piperazine
CAS No.	63854-31-9
Molecular Formula	C11H13F3N2
Molecular Weight	230.23 g/mol
Synonyms	2-(Trifluoromethyl)phenylpiperazine; 1-[2-(Trifluoromethyl)phenyl]piperazine; α,α,α-Trifluoro-o-tolylpiperazine; 2-Trifluoromethylphenylpiperazine; o-Trifluoromethylphenylpiperazine; TFMPP (context-specific); 1-(2-Trifluoromethylphenyl)piperazine; 1-(α,α,α-Trifluoro-o-tolyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-(2-Trifluoromethylphenyl)-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.