Description

18-Hydroxy-All-trans-Retinoic Acid is a hydroxylated derivative of retinoic acid, a key molecule in cellular signaling and differentiation. This compound is of significant interest in advanced pharmaceutical research and development due to its potential role as a more potent or selective metabolite of vitamin A. It is primarily utilized by research institutions and pharmaceutical companies focused on dermatology, oncology, and developmental biology for investigating novel therapeutic pathways.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for the quality control and development of retinoid-based drugs.
• Biochemical Research: Used in studies of cell differentiation, proliferation, and apoptosis to understand retinoid signaling mechanisms.
• Metabolic Pathway Analysis: Investigated as a potential active metabolite in the study of retinoic acid metabolism and its physiological effects.
• Cosmeceutical R&D: Explored in high-end research for its potential applications in anti-aging and skin rejuvenation formulations.
• Academic Research: Employed in universities and research institutes for fundamental studies in genetics and developmental biology.

Basic Information

Product Name	18-Hydroxy-All-trans-Retinoic Acid
CAS No.	63531-93-1
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.43 g/mol
Synonyms	18-Hydroxyretinoic Acid; 18-Hydroxy-tretinoin; all-trans-18-Hydroxyretinoic Acid; (2E,4E,6E,8E)-9-(3-Hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid; 18-OH-ATRA; Vitamin A Acid, 18-Hydroxy-
EINECS	Contact for details

Quality Control

Our 18-Hydroxy-All-trans-Retinoic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
All-trans Isomer Content	≥ 90.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Solubility	Soluble in DMSO, ethanol; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.