Description

Tromethamine Tiaprofenate is a pharmaceutical-grade salt form of the non-steroidal anti-inflammatory drug (NSAID) tiaprofenic acid. This compound is critical for enhancing the solubility and bioavailability of the active pharmaceutical ingredient, facilitating its formulation into stable and effective dosage forms. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of analgesic and anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of finished tiaprofenic acid drug products.
• Analgesic Formulations: Used in the development of solid oral dosage forms (tablets, capsules) for pain relief.
• Anti-inflammatory Medications: A critical component in formulations targeting conditions like osteoarthritis and rheumatoid arthritis.
• Drug Delivery Research: Utilized in studies to improve drug solubility, stability, and controlled release profiles.
• Reference Standard: Serves as a high-purity standard for quality control and analytical method development in pharmaceutical labs.
• Veterinary Pharmaceuticals: Potential application in developing anti-inflammatory treatments for animals.

Basic Information

Product Name	Tromethamine Tiaprofenate
CAS No.	62715-04-2
Molecular Formula	C20H28N2O6S
Molecular Weight	424.51 g/mol
Synonyms	Tiaprofenic Acid Tromethamine Salt; Tiaprofenic Acid Trometamol; Trometamol Tiaprofenate; (2-{5-Benzoyl-2-thienyl}propionic acid) compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); Surgam® (brand name salt form); Tiaprofenic Acid 2-Amino-2-(hydroxymethyl)-1,3-propanediol Salt; Tiaprofenic Acid Tromethamine; Tiaprofenate Tromethamine
EINECS	Contact for details

Quality Control

Our Tromethamine Tiaprofenate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.