Description

Handelin is a bioactive natural product belonging to the class of sesquiterpene lactones, isolated from the plant *Chrysanthemum indicum*. This compound is of significant interest for its role as a key intermediate in the synthesis of complex natural products and for its potential biological activities. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, phytochemical analysis, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research: Serves as a crucial reference standard and intermediate in the development of anti-inflammatory and immunomodulatory drugs.
• Natural Product Chemistry: Used as a pure analytical standard for the identification and quantification of sesquiterpene lactones in plant extracts and herbal formulations.
• Bioactivity Studies: Employed in in vitro and in vivo studies to investigate its potential pharmacological effects, including anti-cancer and neuroprotective properties.
• Chemical Synthesis: Acts as a sophisticated building block for the total synthesis of related natural products and for structure-activity relationship (SAR) studies.
• Cosmeceutical Development: Explored for potential application in high-end skincare products targeting inflammation and oxidative stress.

Basic Information

Product Name	Handelin
CAS No.	62687-22-3
Molecular Formula	C17H22O5
Molecular Weight	306.35 g/mol
Synonyms	Handelin; 8β-Angeloyloxy-1β,10α-epoxy-4α-hydroxy-11(13)-guaien-12,6α-olide; (1aR,4S,6aS,7R,10aS,10bS)-1a,2,3,6a,7,8,9,10,10a,10b-Decahydro-4-hydroxy-7-(2-methyl-1-oxo-2-butenyl)oxy-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9,11-dione
EINECS	Contact for details

Quality Control

Our Handelin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for reference standards, and custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.