Description

1-Palmitoyl-2-Oleoyl-Sn-Glycero-3-Phosphate (POPA) is a high-purity, synthetic phospholipid with a defined fatty acid composition. This compound serves as a critical building block and model membrane component in advanced biochemical and pharmaceutical research. It is essential for researchers and manufacturers in the life sciences sector who require precise, well-characterized lipids for applications such as liposome formulation, membrane biophysics studies, and drug delivery system development.

Application

• Liposome & Nanoparticle Formulation: A key component for creating stable, uniform liposomes used in drug delivery, vaccine adjuvants, and cosmetic encapsulants.
• Membrane Biophysics Research: Used as a standard or model phospholipid to study membrane fluidity, phase behavior, and protein-lipid interactions in artificial bilayer systems.
• Pharmaceutical Excipient: Employed in the development of parenteral and topical formulations where specific phospholipid profiles are required for stability and efficacy.
• Biochemical Assay Standard: Provides a defined substrate for enzymatic assays involving phospholipases or for calibrating analytical instruments like mass spectrometers.
• Cell Culture & Transfection Reagents: A component in complex lipid mixtures used for cell culture media supplements or in the formulation of non-viral transfection agents.
• Reference Material: Serves as a high-purity analytical standard for quality control in the production of other lipid-based products.

Basic Information

Product Name	1-Palmitoyl-2-Oleoyl-Sn-Glycero-3-Phosphate
CAS No.	62600-81-1
Molecular Formula	C37H71O8P
Molecular Weight	674.93 g/mol
Synonyms	POPA; 1-Palmitoyl-2-oleoyl-phosphatidic acid; PA(16:0/18:1); Phosphatidic Acid (16:0/18:1); (2R)-2-Hydroxy-3-(hexadecanoyloxy)propyl (9Z)-octadec-9-enoate hydrogen phosphate; 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate; sn-3-Phosphatidic Acid (16:0/18:1(9Z)); POPA Sodium Salt (when applicable)
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Oleoyl-Sn-Glycero-3-Phosphate is produced under strict quality management protocols. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and fatty acid composition. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. Under these conditions, the product is typically stable for at least two years. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Fatty Acid Composition (GC)	Palmitic acid (C16:0): 45-55% Oleic acid (C18:1): 45-55%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.