Description

(3Ar)-3Aα,4,5,5A,6,7,9Aβ,9Bα-Octahydro-5Aα,9-Dimethyl-3-Methylenenaphtho[1,2-B]Furan-2(3H)-One is a high-purity, complex sesquiterpene lactone derivative with a unique fused ring structure. This specialized intermediate is valued for its stereochemical complexity and functional groups, making it a critical building block in advanced organic synthesis. It is primarily sought by research institutions and pharmaceutical development companies for the synthesis of novel bioactive compounds and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for complex natural product analogs.
• Organic Synthesis Building Block: Utilized in advanced synthetic chemistry for constructing complex polycyclic frameworks due to its intricate stereochemistry and reactive methylene group.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs targeting various therapeutic areas.
• Fine Chemical Production: Acts as a starting material or intermediate in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific stereoisomers.
• Academic & Industrial R&D: Used in methodological development and catalysis research focused on stereoselective transformations and ring-forming reactions.

Basic Information

Item	Detail
Product Name	(3Ar)-3Aα,4,5,5A,6,7,9Aβ,9Bα-Octahydro-5Aα,9-Dimethyl-3-Methylenenaphtho[1,2-B]Furan-2(3H)-One
CAS No.	62458-57-5
Molecular Formula	C15H20O2
Molecular Weight	232.32 g/mol
Synonyms	Alantolactone Isomer; Isoalantolactone (specific stereoisomer); (3aR,5aS,9aR,9bS)-3a,4,5,5a,6,7,9a,9b-Octahydro-5a,9-dimethyl-3-methylenenaphtho[1,2-b]furan-2(3H)-one; Helenin (related compound); Inula helenium lactone derivative; Elecampane camphor analog; (3aR,5aS,9aR,9bS)-5a,9-Dimethyl-3-methylidene-3a,4,5,5a,6,7,9a,9b-octahydronaphtho[1,2-b]furan-2-one
EINECS	Contact for details

Quality Control

Our (3Ar)-3Aα,4,5,5A,6,7,9Aβ,9Bα-Octahydro-5Aα,9-Dimethyl-3-Methylenenaphtho[1,2-B]Furan-2(3H)-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive; prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to maintain quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% de (by Chiral HPLC)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.