Description

Pyrrolidine, 2-[2-[1-(4-Chlorophenyl)-1-Phenylethoxy]Ethyl]-1-Methyl-, [R-(R*,S*)]-, (E)-2-Butenedioate (1:1) is a high-purity, single-isomer pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in advanced organic synthesis and drug development.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of proprietary drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Utilized as a sophisticated reagent or ligand in catalytic asymmetric reactions to induce high enantiomeric excess in target molecules.
• Medicinal Chemistry Research: Serves as a valuable scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities in R&D laboratories.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for new APIs under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in regulatory filings.

Basic Information

Product Name	Pyrrolidine, 2-[2-[1-(4-Chlorophenyl)-1-Phenylethoxy]Ethyl]-1-Methyl-, [R-(R*,S*)]-, (E)-2-Butenedioate (1:1)
CAS No.	61826-32-2
Molecular Formula	C25H30ClNO5
Molecular Weight	460.0 g/mol
Synonyms	(2R,3S)-1-Methyl-2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]pyrrolidinium (E)-but-2-enedioate; Fumarate salt of (2R,3S)-1-Methyl-2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]pyrrolidine; (R-(R*,S*))-2-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate (1:1); 1-Methyl-2-[2-[α-(4-chlorophenyl)-α-phenylbenzyloxy]ethyl]pyrrolidine fumarate; Fumaric acid compound with (2R,3S)-1-methyl-2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]pyrrolidine (1:1)
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 2-[2-[1-(4-Chlorophenyl)-1-Phenylethoxy]Ethyl]-1-Methyl-, [R-(R*,S*)]-, (E)-2-Butenedioate (1:1) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,3S isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.