Description

2-Chloro-6-(Trifluoromethyl)Pyrazine is a versatile halogenated pyrazine derivative, distinguished by its trifluoromethyl and chloro substituents which impart unique reactivity and physicochemical properties. This compound serves as a critical high-value building block in advanced organic synthesis, enabling the introduction of both halogen and fluorine-containing motifs into target molecules. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Employed in the synthesis of specialized ligands, functionalized polymers, and electronic materials requiring specific halogenated heterocyclic structures.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) due to the reactivity of the chlorine atom, facilitating the construction of complex molecular architectures.
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and agrochemical discovery programs.

Basic Information

Product Name	2-Chloro-6-(Trifluoromethyl)Pyrazine
CAS No.	61655-69-4
Molecular Formula	C5H2ClF3N2
Molecular Weight	182.53 g/mol
Synonyms	2-Chloro-6-(trifluoromethyl)pyrazine; 6-Chloro-3-(trifluoromethyl)pyrazine; 2-Chloro-6-trifluoromethylpyrazine; Pyrazine, 2-chloro-6-(trifluoromethyl)-; 61655-69-4; 2-Chloro-6-(trifluoromethyl)-1,4-diazine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-(Trifluoromethyl)Pyrazine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing including HPLC, GC, and NMR analysis to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.