Description

n-Isopropyl-4-[[1-(3-Oxo-3-Phenylpropyl)-1H-Benzimidazol-2-Yl]Methyl]Piperazine-1-Acetamide Dimaleate is a high-purity, non-racemic pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents, particularly within the central nervous system (CNS) and cardiovascular drug categories.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of proprietary drug candidates.
• API Development: Used in research and development for constructing complex molecular architectures with specific biological activity.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical labs.
• Asymmetric Synthesis: Utilized in academic and industrial research exploring new catalytic asymmetric transformations.
• Process Chemistry: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-Isopropyl-4-[[1-(3-Oxo-3-Phenylpropyl)-1H-Benzimidazol-2-Yl]Methyl]Piperazine-1-Acetamide Dimaleate
CAS No.	60960-29-4
Molecular Formula	C31H39N5O7
Molecular Weight	593.67 g/mol
Synonyms	4-[[1-(3-Oxo-3-phenylpropyl)-1H-benzimidazol-2-yl]methyl]-N-(1-methylethyl)-1-piperazineacetamide dimaleate; 1-Piperazineacetamide, 4-[[1-(3-oxo-3-phenylpropyl)-1H-benzimidazol-2-yl]methyl]-N-(1-methylethyl)-, (2Z)-2-butenedioate (1:2); Isopropyl-4-((1-(3-oxo-3-phenylpropyl)-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)acetamide dimaleate; Benzimidazole-piperazine dimaleate derivative; 60960-29-4 (CAS Name).
EINECS	Contact for details

Quality Control

Our n-Isopropyl-4-[[1-(3-Oxo-3-Phenylpropyl)-1H-Benzimidazol-2-Yl]Methyl]Piperazine-1-Acetamide Dimaleate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.