Description

Cholan-24-Oic Acid, 12-Hydroxy-3-(Sulfooxy)-, Disodium Salt, (3α,5β,12α)- (9Ci) is a high-purity, chemically defined bile acid derivative, specifically a disodium salt of a sulfated hydroxy cholic acid. This compound is critical for research and development in pharmaceutical chemistry, particularly in the study of bile acid metabolism and as a reference standard. It serves as a key intermediate and analytical standard for scientists and manufacturers in the life sciences sector requiring precise molecular structures for metabolic pathway analysis and drug discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Biochemical Research: Essential for in-vitro studies of bile acid transporters, nuclear receptors (e.g., FXR, TGR5), and metabolic signaling pathways.
• Metabolite Synthesis: Acts as a key synthetic intermediate or precursor for the preparation of more complex bile acid conjugates and labeled analogs.
• Diagnostic Reagent Development: Employed in the formulation of calibration kits and reagents for clinical diagnostics related to liver function and cholestasis.
• Academic Research: Utilized in university and institutional labs for fundamental research into sterol biochemistry and gastroenterology.

Basic Information

Product Name	Cholan-24-Oic Acid, 12-Hydroxy-3-(Sulfooxy)-, Disodium Salt, (3α,5β,12α)- (9Ci)
CAS No.	60237-35-6
Molecular Formula	C24H37Na2O8S
Molecular Weight	530.58 g/mol
Synonyms	Disodium 3-sulfooxy-12α-hydroxy-5β-cholan-24-oate; 12α-Hydroxy-3-sulfooxy-5β-cholan-24-oic Acid Disodium Salt; 3-Sulfate of 12α-Hydroxycholic Acid Disodium Salt; Taurohyodeoxycholic Acid 3-Sulfate Disodium Salt (related); Sulfated Lithocholic Acid Derivative; Sodium Taurohyocholate Sulfate; Bile Acid Sulfate Ester Salt
EINECS	Contact for details

Quality Control

Our Cholan-24-Oic Acid, 12-Hydroxy-3-(Sulfooxy)-, Disodium Salt is produced under a strict quality management system. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and mass spectrometry to confirm identity, purity, and conformity to specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.