Description

Cucurbitacins CAS NO 60137-06-6 are a class of highly oxygenated tetracyclic triterpenoids primarily isolated from plants of the Cucurbitaceae family. These compounds are of significant commercial and research interest due to their potent bioactivity, which includes cytotoxic, anti-inflammatory, and anti-cancer properties. They are essential raw materials for the pharmaceutical, nutraceutical, and life science research industries, where they are used in drug discovery, biochemical studies, and the development of natural health products.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in anti-cancer and anti-inflammatory drug discovery programs.
• Biochemical & Cell Biology Studies: Used as a potent and specific JAK/STAT signaling pathway inhibitor to study cell proliferation, apoptosis, and tumor biology in vitro.
• Natural Product Isolation & Standardization: Serves as a certified reference material for the quality control and standardization of herbal extracts from bitter melon, pumpkin, and other cucurbit plants.
• Academic & Institutional Research: A critical tool for universities and research institutes investigating the mechanisms of triterpenoid bioactivity and natural product chemistry.
• Nutraceutical Formulation: Employed in the development of high-potency dietary supplements targeting specific wellness pathways, following appropriate safety evaluations.
• Agrochemical Research: Studied for its potential as a natural insecticidal or plant growth-regulating agent due to its bitter taste and biological effects.

Basic Information

Product Name	Cucurbitacins
CAS No.	60137-06-6
Molecular Formula	C32H46O8
Molecular Weight	558.71 g/mol
Synonyms	Cucurbitacin I; Cucurbitacin I (JAK/STAT inhibitor); Elatericin A; JSI-124; (23E)-25-Acetoxy-2,16,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione; 19-Norlanosta-1,5,23-triene-2,16,20,25-tetrol, 3,11,22-trione, 9-methyl-, 25-acetate, (2β,9β,10α,16α,23E)-
EINECS	Contact for details

Quality Control

Our Cucurbitacins are produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production standards. Our quality system is designed to meet the rigorous demands of pharmaceutical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.