Description

1(Alpha) 25-Dihydroxyvitamin D2* is a biologically active metabolite of vitamin D2 (ergocalciferol), playing a critical role in calcium and phosphate homeostasis. This high-purity compound is essential for research and development in endocrinology and bone metabolism studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and manufacturers of diagnostic reagents and reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quality control and assay validation of vitamin D-based pharmaceuticals and supplements.
• Biochemical Research: Used in in vitro and in vivo studies to investigate the mechanisms of vitamin D receptor (VDR) activation, gene regulation, and calcium signaling pathways.
• Diagnostic Kit Development: A key calibrant and component in the development of immunoassays and LC-MS/MS methods for the precise quantification of vitamin D metabolites in clinical samples.
• Metabolite Studies: Employed in metabolic and pharmacokinetic research to understand the conversion and activity of vitamin D2 analogs.
• Cell Culture & Differentiation: Applied in specialized cell culture media to study its effects on cell proliferation, differentiation, and function in bone, immune, and other VDR-expressing cells.

Basic Information

Product Name	1(Alpha) 25-Dihydroxyvitamin D2*
CAS No.	60133-18-8
Molecular Formula	C28H44O3
Molecular Weight	428.65 g/mol
Synonyms	1α,25-Dihydroxyergocalciferol; 1α,25-Dihydroxyvitamin D2; 1α,25(OH)2D2; 1α,25-Dihydroxyvitamin D2*; Paricalcitol Impurity/Intermediate; (1α,3β,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,25-triol; 1α,25-Dihydroxy-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol; ER-1251
EINECS	Contact for details

Quality Control

Our 1(Alpha) 25-Dihydroxyvitamin D2* is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/UV)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.