Description

(3R,3'R,15-Cis)-B,B-Carotene-3,3'-Diol CAS NO 60046-54-0 is a specific stereoisomer of zeaxanthin, a naturally occurring xanthophyll carotenoid. This compound is valued for its potent antioxidant properties and its role as a key visual pigment in biological systems. It is essential for manufacturers in the nutraceutical, food, and cosmetic industries seeking high-purity, bioavailable ingredients for health and coloration applications.

Application

• Dietary Supplements & Nutraceuticals: A critical ingredient in eye health formulas, particularly those targeting Age-Related Macular Degeneration (AMD), due to its selective accumulation in the macula lutea.
• Functional Food & Beverage Fortification: Used as a natural colorant (yellow to orange hues) and a functional nutrient to enhance the antioxidant profile of products like juices, dairy, and baked goods.
• Cosmetic & Personal Care: Incorporated into skincare formulations for its antioxidant benefits, helping to protect skin from oxidative stress and environmental damage.
• Animal & Aquaculture Feed: Added to feed for poultry (to enhance egg yolk color) and farmed fish (like salmon) to improve flesh pigmentation and overall health.
• Pharmaceutical Research: Serves as a reference standard and an active pharmaceutical ingredient (API) in clinical studies focused on ocular and metabolic health.
• Clinical Nutrition: Used in medical food products designed for patients with specific nutritional deficiencies or requirements related to carotenoid intake.

Basic Information

Product Name	(3R,3'R,15-Cis)-B,B-Carotene-3,3'-Diol
CAS No.	60046-54-0
Molecular Formula	C₄₀H₅₆O₂
Molecular Weight	568.87 g/mol
Synonyms	15-cis-Zeaxanthin; (3R,3'R)-Zeaxanthin (15-cis-); (3R,3'R,15Z)-Zeaxanthin; all-trans-Zeaxanthin isomer; beta,β-Carotene-3,3'-diol, (3R,3'R,15-cis)-; Lutein isomer; Xanthophyll; Food Orange 8 (related); E161h (when used as a food additive)
EINECS	Contact for details

Quality Control

Our (3R,3'R,15-Cis)-Zeaxanthin is produced and tested under strict quality management systems. Each batch is analyzed to meet rigorous specifications for identity, purity, and isomer content, typically via HPLC and spectroscopic methods. We support compliance with relevant standards for nutraceutical and food-grade ingredients. Certificates of Analysis (COA) detailing purity, heavy metals, residual solvents, and microbiological parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C (refrigerated) or as specified on the label. For long-term storage, keep at -20°C. The material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Orange to red-orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (UV-Vis)	Conforms
Assay (HPLC)	≥ 95.0% (Total Zeaxanthin Isomers)
Isomeric Purity (15-cis)	≥ 90.0% (of total Zeaxanthin)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Total Plate Count	≤ 1000 cfu/g
Yeast & Mold	≤ 100 cfu/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.