Description

3,6-Diphenyl-1,2,4,5-Tetrazine is a high-value, heterocyclic organic compound belonging to the s-tetrazine class, known for its distinctive purple color and excellent properties as a dienophile in inverse electron-demand Diels-Alder (IEDDA) reactions. This compound matters for its critical role as a bioorthogonal reagent, enabling highly selective and rapid bioconjugation under mild physiological conditions without interfering with native biological processes. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science industries for applications such as drug discovery, bioimaging, and the development of advanced polymers.

Application

• Bioorthogonal Chemistry: A key reagent for IEDDA click chemistry with trans-cyclooctene (TCO) for selective labeling of biomolecules in live cells.
• Pharmaceutical Development: Used in the synthesis of antibody-drug conjugates (ADCs) and for pretargeted radioimmunotherapy strategies.
• Diagnostic Imaging: Facilitates the site-specific attachment of fluorescent dyes or radionuclides for in vivo and in vitro imaging.
• Polymer & Materials Science: Serves as a cross-linking agent or functional monomer for creating smart materials and hydrogels.
• Chemical Biology: Enables the study of biomolecular interactions, trafficking, and localization through selective tagging.
• Academic & Industrial R&D: A fundamental building block for novel synthetic methodologies and probe development.

Basic Information

Product Name	3,6-Diphenyl-1,2,4,5-Tetrazine
CAS No.	6830-78-0
Molecular Formula	C14H10N4
Molecular Weight	234.26 g/mol
Synonyms	1,2,4,5-Tetrazine, 3,6-diphenyl-; DPTZ; 3,6-Diphenyl-s-tetrazine; Diphenyltetrazine; s-Tetrazine, 3,6-diphenyl-; 3,6-Diphenyl-1,2,4,5-tetrazine; NSC 51117; Bicyclo[2.2.2]octa-2,5,7-triene, 1,4-diphenyl-
EINECS	229-915-9

Quality Control

Our 3,6-Diphenyl-1,2,4,5-Tetrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive bioorthogonal applications. Certificates of Analysis (COA) detailing purity, appearance, and specific analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Dark purple to violet crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	205 - 210 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.