Description

Helenalin is a potent sesquiterpene lactone, a natural product derived from plants of the *Arnica* genus. This compound is of significant interest due to its well-documented biological activity, particularly its anti-inflammatory and anti-cancer properties. It serves as a critical reference standard and research chemical for pharmaceutical R&D, natural product chemistry, and molecular biology studies.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in studies targeting inflammation and oncology.
• Biochemical Research: Employed as a selective inhibitor of the NF-κB signaling pathway to study cellular mechanisms of inflammation and apoptosis.
• Natural Product Chemistry: Serves as a high-purity analytical standard for the identification and quantification of sesquiterpene lactones in plant extracts and herbal products.
• Cell Biology Studies: Utilized in *in vitro* assays to investigate its effects on various cancer cell lines and its potential chemotherapeutic mechanisms.
• Anti-inflammatory Agent Development: Acts as a lead compound for the synthesis and development of novel anti-inflammatory drugs.
• Academic & Institutional Research: Supplied to universities and research institutes for pharmacological and phytochemical studies.

Basic Information

Product Name	Helenalin
CAS No.	6754-13-8
Molecular Formula	C15H18O4
Molecular Weight	262.30 g/mol
Synonyms	Helenalin; 4,5,6,7,8,8a-Hexahydro-3,8-dimethyl-5-methyleneazuleno[6,5-b]furan-2,8-dione; 2(3H)-Naphtho[2,3-b]furanone, 4,4a,5,6,7,8-hexahydro-3,6-dimethyl-5-methylene-, (4aS,6R)-; Arnicin; Arnicolide C; (-)-Helenalin
EINECS	Contact for details

Quality Control

Our Helenalin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.