Description

p-Tolylmagnesium Chloride is a versatile organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry for the formation of carbon-carbon bonds. Its primary value lies in its ability to act as a nucleophile, introducing the valuable p-tolyl (4-methylphenyl) group into a wide array of electrophilic substrates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, enabling the synthesis of complex molecules, intermediates, and fine chemicals. Its controlled reactivity makes it a cornerstone for constructing tailored molecular architectures in both laboratory and pilot-scale production.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the p-tolyl moiety into active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the production of herbicides, fungicides, and insecticides where the 4-methylphenyl group imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and polymerization.
• Fine Chemical and Specialty Material Production: Employed in the synthesis of dyes, pigments, liquid crystals, and organic electronic materials.
• Academic and R&D Laboratories: A fundamental reagent for methodological development and exploratory synthesis in organic chemistry research.
• Cross-Coupling Reactions: Acts as a coupling partner in reactions such as Kumada coupling for the formation of biaryl structures.

Basic Information

Product Name	p-Tolylmagnesium Chloride
CAS No.	696-61-7
Molecular Formula	C7H7ClMg
Molecular Weight	150.89 g/mol
Synonyms	4-Methylphenylmagnesium Chloride; (4-Methylphenyl)magnesium Chloride; p-Methylphenylmagnesium Chloride; 4-Tolylmagnesium Chloride; Magnesium, chloro(4-methylphenyl)-; 1-Methyl-4-magnesiochlorobenzene; Grignard Reagent p-TolylMgCl; Tolylmagnesium Chloride solution
EINECS	211-795-6

Quality Control

Our p-Tolylmagnesium Chloride is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. We provide comprehensive analytical data, including titration for Grignard concentration and GC analysis for solvent purity and byproducts. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting key parameters such as assay, appearance, and solution concentration. Our quality management system supports compliance with cGMP and ISO standards where required for advanced manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive nature, this product must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. For solutions, typical recommended storage temperature is 2-8°C to maintain stability and reactivity. Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow liquid
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR)	Conforms to structure
Solvent (Typical)	Tetrahydrofuran (THF) or Diethyl Ether
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.