Description

2,3-Dihydro-1-Hydroxy-1H-Phosphole 1-Oxide is a specialized organophosphorus compound featuring a unique five-membered phosphole ring structure. This heterocyclic building block is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced material science and pharmaceutical research. It is primarily sought by R&D chemists and process development teams in the fine chemical, agrochemical, and pharmaceutical industries for creating novel ligands, catalysts, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting neurological and metabolic pathways.
• Ligand Synthesis: Used to create specialized phosphine-based ligands for homogeneous catalysis in asymmetric synthesis and cross-coupling reactions.
• Agrochemical Research: Serves as a building block for developing new generations of herbicides, fungicides, and plant growth regulators.
• Material Science: Employed in the development of flame retardants, polymer modifiers, and specialty additives due to its phosphorus-containing core.
• Coordination Chemistry: Acts as a chelating agent or precursor for metal-organic frameworks (MOFs) and other coordination complexes.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2,3-Dihydro-1-Hydroxy-1H-Phosphole 1-Oxide
CAS No.	694-24-6
Molecular Formula	C4H7O2P
Molecular Weight	118.07 g/mol
Synonyms	1-Hydroxy-2,3-dihydro-1H-phosphole 1-oxide; 1H-Phosphole-1-ol, 2,3-dihydro-, 1-oxide; 1-Hydroxyphospholane 1-oxide; Dihydroxyphospholene oxide; Phospholanol 1-oxide; Contact for details on additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our production of 2,3-Dihydro-1-Hydroxy-1H-Phosphole 1-Oxide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.