Description

Metformin CAS NO 657-24-9 is a biguanide-class pharmaceutical compound widely recognized as a first-line medication for the management of type 2 diabetes. Its primary value lies in its ability to effectively lower blood glucose levels by decreasing hepatic glucose production and improving insulin sensitivity. This high-purity active pharmaceutical ingredient (API) is essential for global pharmaceutical manufacturers producing oral anti-diabetic formulations. Consistent quality and reliable supply are critical for ensuring the safety and efficacy of the final drug product.

Application

• Pharmaceutical API: Primary use as the active ingredient in immediate-release and extended-release tablets for type 2 diabetes treatment.
• Combination Therapies: Used in fixed-dose combination drugs with other anti-diabetic agents like sulfonylureas, DPP-4 inhibitors, or SGLT2 inhibitors.
• Polycystic Ovary Syndrome (PCOS) Treatment: Employed off-label to manage insulin resistance and related symptoms in PCOS.
• Veterinary Medicine: Applied in veterinary practice for the management of insulin resistance in animals, particularly in equine metabolic syndrome.
• Research & Development: Serves as a key reference standard and starting material in metabolic disorder research and new drug development.
• Pre-Formulation Studies: Used in pharmaceutical R&D for solubility, stability, and compatibility testing during drug formulation design.

Basic Information

Product Name	Metformin
CAS No.	657-24-9
Molecular Formula	C4H11N5
Molecular Weight	129.16 g/mol
Synonyms	Metformin Hydrochloride (common salt form); 1,1-Dimethylbiguanide; N,N-Dimethylimidodicarbonimidic diamide; Dimethylbiguanide; Glucophage (brand name); Metformina; Metforminum; LA-6023; Flumamine; Diabefagos; Meguan
EINECS	211-517-8

Quality Control

Our Metformin is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. We offer grades compliant with major pharmacopoeias, including USP, EP, and BP monographs. Every batch undergoes comprehensive analytical testing, including assay, identification, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, store in a cool, dry place at controlled room temperature (15-25°C). The container should be kept in a well-ventilated area with low humidity to prevent moisture absorption and caking. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (on dried basis)	98.5% - 101.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 0.5% Any individual impurity ≤ 0.1%
Microbiological Enumeration	Total aerobic microbial count ≤ 1000 cfu/g Total combined yeasts/molds ≤ 100 cfu/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.