Description

Bis-Trifluoromethyl Ethylphosphonate is a high-value organophosphorus compound featuring two trifluoromethyl groups, which impart unique chemical and physical properties. This compound is critical for applications requiring advanced fluorinated intermediates with specific reactivity and stability profiles. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for synthesizing novel active ingredients, as well as by specialty chemical manufacturers.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of fluorinated drug candidates, potentially enhancing metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms can improve efficacy and environmental profile.
• Ligand and Catalyst Precursor: Acts as a precursor for specialized phosphonate ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the creation of fluorinated polymers or surface modifiers to alter material properties like hydrophobicity and chemical resistance.
• Organic Synthesis Reagent: Functions as a versatile reagent for introducing the bis(trifluoromethyl)phosphonate moiety into complex organic molecules.
• Chemical Research & Development: A valuable tool for medicinal and process chemists exploring new synthetic pathways and compound libraries.

Basic Information

Product Name	Bis-Trifluoromethyl Ethylphosphonate
CAS No.	650-16-8
Molecular Formula	C5H7F6O3P
Molecular Weight	236.08 g/mol
Synonyms	Ethyl Bis(trifluoromethyl)phosphonate; Diethyl Bis(trifluoromethyl)phosphonate (common misnomer); (Ethoxy)bis(trifluoromethyl)phosphine Oxide; Phosphonic acid, P,P-bis(trifluoromethyl)-, ethyl ester; Ethyl P,P-Bis(trifluoromethyl)phosphonate; NSC 5185
EINECS	Contact for details

Quality Control

Our Bis-Trifluoromethyl Ethylphosphonate is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹⁹F, ³¹P), GC/HPLC for purity, and Karl Fischer titration for water content, to ensure it meets precise customer specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.