Description

Tolbutamide CAS NO 64-77-7 is a first-generation sulfonylurea compound that functions as an oral hypoglycemic agent. It is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) used in the research and development of diabetes management therapies. This compound is essential for pharmaceutical manufacturers, research institutions, and chemical suppliers serving the global healthcare and life sciences sectors.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral anti-diabetic medications for the management of type 2 diabetes mellitus.
• Biochemical Research: Used as a reference standard and tool compound in metabolic studies, particularly research focused on insulin secretion and pancreatic β-cell function.
• Pharmacology Development: Serves as a key intermediate in the synthesis and development of new sulfonylurea-based therapeutic agents.
• Quality Control & Testing: Employed as an analytical standard in pharmaceutical quality control laboratories for method development and validation.
• Academic Research: Utilized in university and institutional labs for teaching and investigating the mechanisms of action of hypoglycemic drugs.

Basic Information

Product Name	Tolbutamide
CAS No.	64-77-7
Molecular Formula	C12H18N2O3S
Molecular Weight	270.35 g/mol
Synonyms	1-Butyl-3-(p-tolylsulfonyl)urea; 1-Butyl-3-(4-methylphenyl)sulfonylurea; Orinase; Rastinon; Artosin; Diabetol; Dolipol; Ipoglicone; Tolbutamidum; Tolbutamid; AGIP 60; N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
EINECS	200-596-5

Quality Control

Our Tolbutamide is manufactured under strict quality management systems. It is typically supplied to meet high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.