Description

2,4-Thiazolidinedione,3-[(4-Fluorophenyl)Methyl]-5-[[1-(2-Propenyl)-1H-Indol-3-Yl]Methylene]-(9Ci) is a high-purity, advanced pharmaceutical intermediate belonging to the thiazolidinedione class of compounds. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting metabolic and inflammatory pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those targeting PPAR (Peroxisome Proliferator-Activated Receptor) pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity in drug discovery programs.
• Biochemical Research: Serves as a reference standard or a tool compound in metabolic disease research, including studies on diabetes and insulin sensitization.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex, functionalized molecules with specific biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for exploratory research in organic synthesis and pharmacology.

Basic Information

Product Name	2,4-Thiazolidinedione,3-[(4-Fluorophenyl)Methyl]-5-[[1-(2-Propenyl)-1H-Indol-3-Yl]Methylene]-(9Ci)
CAS No.	593275-77-5
Molecular Formula	C22H17FN2O2S
Molecular Weight	392.45 g/mol
Synonyms	3-[(4-Fluorophenyl)methyl]-5-{[1-(prop-2-en-1-yl)-1H-indol-3-yl]methylene}-1,3-thiazolidine-2,4-dione; 3-(4-Fluorobenzyl)-5-[(1-allyl-1H-indol-3-yl)methylene]thiazolidine-2,4-dione; 5-[(1-Allyl-1H-indol-3-yl)methylene]-3-[(4-fluorophenyl)methyl]-2,4-thiazolidinedione; (5Z)-5-[(1-Allyl-1H-indol-3-yl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione; 593275-77-5 (CAS); TZD derivative; PPAR modulator intermediate.
EINECS	Contact for details

Quality Control

Our 2,4-Thiazolidinedione derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment ensures the material is suitable for demanding research and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.