Description

Pyrrolo[1,2-A]Pyrazine-3-Carboxamide, n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined bicyclic structure. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent, selective drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its unique fused heterocyclic scaffold.
• Process Chemistry & Scale-Up: Serves as a key starting material (KSM) or advanced intermediate for developing robust, scalable GMP manufacturing routes for new chemical entities (NCEs).
• Reference Standard: Supplied as a high-purity analytical standard for method development, quality control, and regulatory submissions.
• Biochemical Tool Compound: Utilized in vitro and in vivo to probe specific biological pathways and validate novel therapeutic targets.

Basic Information

Product Name	Pyrrolo[1,2-A]Pyrazine-3-Carboxamide, n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-
CAS No.	588720-50-7
Molecular Formula	C12H16N4O
Molecular Weight	232.28 g/mol
Synonyms	(1R,3R,4S)-N-(1-Azabicyclo[2.2.1]hept-3-yl)pyrrolo[1,2-a]pyrazine-3-carboxamide; (1R,3R,4S)-3-[(Pyrrolo[1,2-a]pyrazine-3-carbonyl)amino]-1-azabicyclo[2.2.1]heptane; UNII-7S8K1168QN; 7S8K1168QN; Pyrrolo[1,2-a]pyrazine-3-carboxamide, N-[(1R,3R,4S)-1-azabicyclo[2.2.1]hept-3-yl]-; ATC code N06AX
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems, ensuring batch-to-batch consistency and traceability. Each lot is subjected to comprehensive analytical characterization, including Chiral HPLC to confirm stereochemical purity and NMR for structural verification. We provide detailed Certificates of Analysis (COA) with each shipment, documenting purity, identity, and impurity profiles. Our quality commitment supports development from research to commercial scale, aligning with cGMP principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.