Description

4-Cbz-1-Boc 2-(Hydroxymethyl)Piperazine is a high-purity, multi-functional piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications such as peptide mimetics and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Chemistry: Serves as a constrained scaffold to mimic peptide secondary structures, enhancing metabolic stability and bioavailability of drug candidates.
• Ligand and Catalyst Development: Used in the synthesis of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Protecting Group Strategy: The orthogonal Cbz (carboxybenzyl) and Boc (tert-butoxycarbonyl) protecting groups allow for selective deprotection in multi-step synthetic sequences.
• Chemical Biology Probes: Incorporation into molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) and CDMOs producing complex molecules at various scales.

Basic Information

Product Name	4-Cbz-1-Boc 2-(Hydroxymethyl)Piperazine
CAS No.	557056-07-2
Molecular Formula	C18H26N2O5
Molecular Weight	350.41 g/mol
Synonyms	1-Boc-4-Cbz-2-(Hydroxymethyl)Piperazine; 2-(Hydroxymethyl)-1,4-bis(oxycarbonyl)piperazine (Boc/Cbz); tert-Butyl 4-[(benzyloxy)carbonyl]-2-(hydroxymethyl)piperazine-1-carboxylate; 1-N-Boc-4-N-Cbz-2-(Hydroxymethyl)piperazine; 4-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)-2-piperazinemethanol; Piperazine, 2-(hydroxymethyl)-1,4-bis[(phenylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester; Boc-Cbz-Pip(2-CH2OH)-OH; (2-Hydroxymethyl-piperazine-1,4-dicarboxylic acid dibenzyl ester tert-butyl ester)
EINECS	Contact for details

Quality Control

Our 4-Cbz-1-Boc 2-(Hydroxymethyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.