Description

1-(4-Fluorophenyl)-2-Piperazin-1-Ylethanone is a high-purity synthetic intermediate featuring a fluorinated aromatic ring linked to a piperazine moiety via an ethanone bridge. This molecular architecture makes it a valuable building block for pharmaceutical research and development, particularly in the synthesis of novel bioactive compounds. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating targeted molecular libraries and scaling up lead candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, due to the presence of the piperazine pharmacophore.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, where the fluorophenyl group can enhance biological activity and stability.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke chemicals for client projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	1-(4-Fluorophenyl)-2-Piperazin-1-Ylethanone
CAS No.	556807-81-9
Molecular Formula	C12H15FN2O
Molecular Weight	222.26 g/mol
Synonyms	1-(4-Fluorophenyl)-2-(piperazin-1-yl)ethanone; 2-(Piperazin-1-yl)-1-(4-fluorophenyl)ethanone; 4-Fluorophenacylpiperazine; N-(2-Oxo-2-(4-fluorophenyl)ethyl)piperazine; 1-(4-Fluorobenzoyl)methylpiperazine; 556807-81-9
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Fluorophenyl)-2-Piperazin-1-Ylethanone is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including chromatographic purity analysis and structural confirmation, to ensure compliance with exacting customer and research standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.