Description

Resolvin E1 is a specialized pro-resolving lipid mediator (SPM) derived from the ω-3 fatty acid eicosapentaenoic acid (EPA). This compound is of significant interest for its potent and specific role in actively resolving inflammation and promoting tissue homeostasis without causing immunosuppression. It is primarily utilized in advanced pharmaceutical research and biochemical studies focused on inflammation, immunology, and metabolic disorders.

Application

• Biomedical Research: A critical reference standard and active agent in studies investigating the molecular mechanisms of inflammation resolution, tissue repair, and immune modulation.
• Drug Discovery & Development: Serves as a lead compound or biological tool for developing novel therapeutics targeting chronic inflammatory diseases such as arthritis, asthma, and inflammatory bowel disease.
• Cell Biology & Signaling Studies: Used to elucidate specific receptor pathways (e.g., ChemR23) and downstream signaling cascades involved in the resolution phase of acute inflammation.
• Metabolic Disorder Research: Investigated for its potential role in improving insulin sensitivity and resolving inflammation associated with obesity and type 2 diabetes.
• Preclinical Model Studies: Applied in animal models to validate efficacy in reducing inflammation and promoting healing in various disease contexts.
• Analytical Standard: Employed as a high-purity standard for method development and quantification in analytical techniques like LC-MS/MS for biomarker analysis.

Basic Information

Product Name	Resolvin E1
CAS No.	552830-51-0
Molecular Formula	C20H30O5
Molecular Weight	350.45 g/mol
Synonyms	RvE1; (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-Trihydroxy-7,9,11,13-icosatetraenoic acid; 5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid; Resolvin E1 (RvE1); 7S,8R,15S-Trihydroxy-5Z,9E,11E,13E-eicosatetraenoic acid
EINECS	Contact for details

Quality Control

Our Resolvin E1 is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and stability are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.