Description

4-(2-Chloro-Pyridine-3-Carbonyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, particularly in the creation of active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is essential for research institutions, CROs, and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Particularly valuable in the synthesis of compounds targeting neurological and psychiatric disorders due to its piperazine and chloropyridine motifs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches under cGMP conditions.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in early-stage drug discovery.
• Process Chemistry: Used in route scouting and process development for the scalable and cost-effective manufacture of target molecules.

Basic Information

Product Name	4-(2-Chloro-Pyridine-3-Carbonyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	551921-02-9
Molecular Formula	C16H20ClN3O3
Molecular Weight	337.80 g/mol
Synonyms	1-Boc-4-(2-chloronicotinoyl)piperazine; tert-Butyl 4-(2-chloropyridine-3-carbonyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(2-chloro-3-pyridinylcarbonyl)piperazine; 4-(2-Chloronicotinoyl)piperazine-1-carboxylic acid tert-butyl ester; Boc-Piperazine-(2-chloro-nicotinoyl); N-Boc-4-(2-chloronicotinoyl)piperazine; 551921-02-9
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Pyridine-3-Carbonyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment supports applications from research to development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.