Description

1-(Piperidin-4-Yl)Pyrrolidin-2-One Hcl is a high-purity pharmaceutical intermediate and building block of significant interest in modern organic synthesis. Its value lies in its versatile piperidine-pyrrolidinone scaffold, which is a privileged structure in medicinal chemistry for modulating biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for designing and synthesizing new chemical entities (NCEs) for biological screening.
• Ligand and Receptor Studies: Employed in the development of probes and ligands for neurological and GPCR-targeted drug discovery.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of candidate drugs.
• Chemical Biology: Acts as a precursor for creating tool compounds to study specific enzymatic pathways or protein functions.
• Custom Synthesis: A key starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.

Basic Information

Product Name	1-(Piperidin-4-Yl)Pyrrolidin-2-One Hcl
CAS No.	548769-02-4
Molecular Formula	C9H17ClN2O
Molecular Weight	204.70 g/mol
Synonyms	1-(4-Piperidinyl)-2-pyrrolidinone hydrochloride; 2-Pyrrolidinone, 1-(4-piperidinyl)-, hydrochloride; 1-(Piperidin-4-yl)pyrrolidin-2-one hydrochloride; 4-(2-Oxopyrrolidin-1-yl)piperidine hydrochloride; 1-Piperidin-4-ylpyrrolidin-2-one HCl; Pyrrolidin-2-one, 1-(4-piperidinyl)-, monohydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Piperidin-4-Yl)Pyrrolidin-2-One Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and related substances to ensure it meets high-grade standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.