Description

(S)-1-Benzyl 4-tert-Butyl 2-(Hydroxymethyl)Piperazine-1,4-Dicarboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile, stereochemically defined scaffold essential for constructing complex molecules with high pharmacological relevance. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for applications in medicinal chemistry, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug candidates.
• Medicinal Chemistry: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable hydroxymethyl and protected amine functionalities.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of chiral APIs, leveraging its defined stereochemistry.
• Peptidomimetics Research: Serves as a constrained, non-natural amino acid analogue in the design of peptide-like molecules with enhanced metabolic stability.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Academic & Institutional Research: Utilized in chemical biology and organic synthesis research projects exploring new synthetic methodologies.

Basic Information

Product Name	(S)-1-Benzyl 4-tert-Butyl 2-(Hydroxymethyl)Piperazine-1,4-Dicarboxylate
CAS No.	529516-61-8
Molecular Formula	C18H26N2O5
Molecular Weight	350.41 g/mol
Synonyms	1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(phenylmethyl)- 4-(1,1-dimethylethyl) ester, (2S)-; (S)-1-Benzyl 4-tert-butyl piperazine-1,4-dicarboxylate-2-methanol; (S)-1-Boc-4-Cbz-2-(hydroxymethyl)piperazine; (S)-N-Boc-N'-Cbz-2-(hydroxymethyl)piperazine; (S)-2-Hydroxymethyl-1-Cbz-4-Boc-piperazine; tert-Butyl (S)-4-benzyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate; (S)-1-(Benzyloxycarbonyl)-4-(tert-butoxycarbonyl)-2-(hydroxymethyl)piperazine
EINECS	Contact for details

Quality Control

Our (S)-1-Benzyl 4-tert-Butyl 2-(Hydroxymethyl)Piperazine-1,4-Dicarboxylate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure identity, purity, and enantiomeric excess meet the highest standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.