Description

14,15-Ee-5(Z)-E is a specialized epoxyeicosatrienoic acid (EET) regioisomer, a key bioactive lipid metabolite derived from arachidonic acid. This compound matters significantly in biochemical research for its role as a potent endogenous signaling molecule involved in vasodilation, anti-inflammatory processes, and cellular protection. Researchers and pharmaceutical developers in the life sciences sector need it for investigating cardiovascular, renal, and metabolic pathways, as well as for developing novel therapeutic agents targeting the cytochrome P450 epoxygenase pathway.

Application

• Biochemical Research: Used as a high-purity reference standard and analytical standard in LC-MS, GC-MS, and HPLC studies to quantify endogenous EET levels.
• Pharmacology & Drug Discovery: Serves as a critical tool compound for studying the biological effects of EETs, including vascular relaxation and anti-hypertensive mechanisms, aiding in the development of EET-based therapeutics or soluble epoxide hydrolase (sEH) inhibitors.
• Cell Signaling Studies: Applied in in vitro cell culture models to elucidate the role of specific EET regioisomers in inflammation, angiogenesis, and apoptosis.
• Enzyme Activity Assays: Utilized as a substrate or product in assays for cytochrome P450 epoxygenases and soluble epoxide hydrolase (sEH) to measure enzyme kinetics and inhibition.
• Metabolomics: An essential component in targeted metabolomics panels for profiling oxylipins and eicosanoids in biological samples like plasma, urine, and tissue homogenates.

Basic Information

Product Name	14,15-Ee-5(Z)-E
CAS No.	519038-92-7
Molecular Formula	C20H32O3
Molecular Weight	320.47 g/mol
Synonyms	14,15-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid; 14(15)-EpETrE; 14,15-EET; 14,15-Epoxyeicosatrienoic Acid; (5Z,8Z,11Z)-14,15-Epoxyeicosa-5,8,11-trienoic Acid; 14,15-Epoxy-5,8,11-eicosatrienoic Acid; 14,15-EE-5(Z)-E; Arachidonic acid 14,15-epoxide
EINECS	Contact for details

Quality Control

Our 14,15-Ee-5(Z)-E is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material for analytical method development and validation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by weight)
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.