Description

Cyclopropanecarboxaldehyde, 2,2,3-Trimethyl-3-Nitro-, (1R,3R)- (9Ci) is a high-purity, chiral nitrocyclopropane derivative, a sophisticated building block prized for its unique three-dimensional structure and stereochemical integrity. This compound matters for enabling the synthesis of complex molecules with precise spatial orientation, a critical requirement in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclopropane ring and nitro group confer specific biological activity and stability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective synthesis.
• Advanced Material Research: Employed in the development of specialty polymers and functional materials that require rigid, three-dimensional molecular scaffolds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways due to its reactive aldehyde and nitro functional groups.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization from laboratory to pilot plant scale, ensuring a reliable supply of a critical chiral intermediate.

Basic Information

Item	Details
Product Name	Cyclopropanecarboxaldehyde, 2,2,3-Trimethyl-3-Nitro-, (1R,3R)- (9Ci)
CAS No.	518352-38-0
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	(1R,3R)-2,2,3-Trimethyl-3-nitrocyclopropanecarboxaldehyde; (1R,3R)-2,2,3-Trimethyl-3-nitrocyclopropanecarbaldehyde; (1R,3R)-3-Nitro-2,2,3-trimethylcyclopropanecarboxaldehyde; (1R,3R)-TNMCPCA; Chiral Nitrocyclopropane Carboxaldehyde; (1R,3R)-TNMCP-CHO; (1R,3R)-3-Nitro-TMCP-CHO
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxaldehyde, 2,2,3-Trimethyl-3-Nitro-, (1R,3R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, it is recommended to handle under an inert atmosphere (e.g., nitrogen or argon) and allow the container to reach ambient temperature before opening to minimize moisture ingress and volatilization loss.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.