Description

Peg4-Acid CAS NO 518044-49-0 is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a terminal carboxylic acid group. This functional handle is critical for creating stable, water-soluble conjugates and bioconjugates through amide bond formation. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise linker chemistry for drug delivery systems, diagnostic reagents, and surface modification.

Application

• Bioconjugation & Drug Delivery: A key linker for attaching therapeutic payloads (e.g., drugs, peptides, proteins) to targeting ligands, antibodies, or nanoparticles to create antibody-drug conjugates (ADCs) and other targeted therapies.
• PEGylation Reagent: Used to PEGylate biomolecules (proteins, peptides) to enhance solubility, increase circulating half-life, and reduce immunogenicity.
• Polymer & Material Science: Serves as a functional monomer or cross-linker for synthesizing hydrogels, smart polymers, and biocompatible coatings with tailored properties.
• Diagnostic Reagents: Employed in the synthesis of contrast agents, fluorescent probes, and assay components where water solubility and biocompatibility are paramount.
• Surface Functionalization: Used to modify surfaces (e.g., gold nanoparticles, quantum dots, sensor chips) with carboxylic acid groups for subsequent biomolecule immobilization.
• Intermediate for Further Derivatization: The carboxylic acid can be readily activated to NHS esters or other reactive species for efficient coupling chemistry.

Basic Information

Product Name	Peg4-Acid
CAS No.	518044-49-0
Molecular Formula	C17H32O9
Molecular Weight	380.43 g/mol
Synonyms	15-Aza-3,6,9,12-tetraoxapentadecan-1-oic acid; 2,5,8,11-Tetraoxatetradecan-14-oic acid; 3,6,9,12-Tetraoxapentadecanoic acid; 17-Amino-5,8,11,14-tetraoxa-2-azaheptadecan-1-oic acid; PEG4-acid; Tetraethylene glycol monoacetic acid; Acetic acid, 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-; HO-PEG4-CH2COOH
EINECS	Contact for details

Quality Control

Our Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistent performance for critical applications. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.