Description

n-Boc-3-Methyl-4-Piperidinecarboxylic Acid is a high-purity, protected piperidine derivative that serves as a critical chiral building block in organic synthesis. Its value lies in providing a versatile and stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis to explore new chemical entities.
• Peptidomimetics Development: Serves as a constrained amino acid analog for designing novel peptide-like molecules with enhanced metabolic stability.
• Agrochemical Synthesis: Employed as a building block for creating advanced fungicides and herbicides with specific stereochemical requirements.
• Ligand and Catalyst Preparation: Useful for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring a protected 3-methylpiperidine-4-carboxylic acid moiety.

Basic Information

Product Name	n-Boc-3-Methyl-4-Piperidinecarboxylic Acid
CAS No.	512822-50-3
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	1-Boc-3-Methyl-4-piperidinecarboxylic Acid; 1-(tert-Butoxycarbonyl)-3-methyl-4-piperidinecarboxylic Acid; 3-Methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic Acid; tert-Butyl 3-methyl-4-carboxypiperidine-1-carboxylate; Boc-3-Methyl-piperidine-4-carboxylic Acid; 4-Piperidinecarboxylic acid, 3-methyl-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our n-Boc-3-Methyl-4-Piperidinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.