Description

(2E)-3-(1-Methyl-1H-Pyrazol-4-Yl)Acryloyl Chloride is a high-value, reactive chemical intermediate featuring an acryloyl chloride moiety linked to a methylpyrazole heterocycle. This compound is critical for introducing the (1-methyl-1H-pyrazol-4-yl)acrylamide pharmacophore into target molecules, enabling the synthesis of advanced active ingredients. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel small-molecule therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the production of modern fungicides and herbicides with specific mode-of-action.
• Chemical Biology & Proteomics: Serves as a reactive handle for creating activity-based probes (ABPs) to study enzyme function.
• Material Science Research: Employed in the development of functional polymers and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	(2E)-3-(1-Methyl-1H-Pyrazol-4-Yl)Acryloyl Chloride
CAS No.	512809-95-9
Molecular Formula	C7H7ClN2O
Molecular Weight	170.60 g/mol
Synonyms	(E)-3-(1-Methyl-1H-pyrazol-4-yl)acryloyl chloride; 3-(1-Methyl-1H-pyrazol-4-yl)propenoyl chloride; 2-Propenoyl chloride, 3-(1-methyl-1H-pyrazol-4-yl)-, (2E)-; 1-Methyl-4-(3-chloro-3-oxo-1-propenyl)-1H-pyrazole; (2E)-3-(1-Methyl-1H-pyrazol-4-yl)acrylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of (2E)-3-(1-Methyl-1H-Pyrazol-4-Yl)Acryloyl Chloride is manufactured and tested under strict quality management systems to ensure consistency and reliability for critical R&D and scale-up processes. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.