Description

(S)-2-(4-Fluorophenyl)Morpholine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its role in the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals requiring a specific stereochemical configuration. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the (S)-enantiomer provides specific biological activity.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in regulatory submissions.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and process chemistry optimization in laboratory and pilot-scale settings.

Basic Information

Product Name	(S)-2-(4-Fluorophenyl)Morpholine Hydrochloride
CAS No.	503860-58-0
Molecular Formula	C10H13FNO•HCl
Molecular Weight	217.68 g/mol (Free base: 181.22)
Synonyms	(S)-2-(4-Fluorophenyl)morpholine hydrochloride; (4S)-4-(4-Fluorophenyl)morpholine hydrochloride; (S)-4-(4-Fluorophenyl)morpholine HCl; (S)-2-(p-Fluorophenyl)morpholine hydrochloride; (S)-para-Fluorophenylmorpholine hydrochloride; Morpholine, 2-(4-fluorophenyl)-, hydrochloride, (2S)-; (S)-(-)-2-(4-Fluorophenyl)morpholine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-(4-Fluorophenyl)Morpholine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.