Description

n-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-5-[(1E)-2-[(2S,4R)-Tetrahydro-4-Hydroxy-6-Oxo-2H-Pyran-2-Yl]Ethenyl]-2-Pyrimidinyl]-n-Methylmethanesulfonamide is a high-purity, complex organic compound featuring a pyrimidine core with a fluorophenyl substituent and a chiral dihydropyranone moiety. This compound is valued as a critical pharmaceutical intermediate for the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, target-specific drug molecules.
• API Development: Used in research and development for creating new active pharmaceutical ingredients, particularly in areas like oncology and metabolic diseases.
• Chemical Synthesis Research: Serves as a sophisticated substrate or reagent in methodological studies and asymmetric synthesis.
• Preclinical & Clinical Trial Material: Supplied in high-purity grades for use in non-clinical studies and the manufacture of clinical trial batches.
• Process Chemistry: Utilized in route scouting and optimization for scalable API manufacturing processes.

Basic Information

Product Name	n-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-5-[(1E)-2-[(2S,4R)-Tetrahydro-4-Hydroxy-6-Oxo-2H-Pyran-2-Yl]Ethenyl]-2-Pyrimidinyl]-n-Methylmethanesulfonamide
CAS No.	503610-43-3
Molecular Formula	C22H26FN3O5S
Molecular Weight	463.52 g/mol
Synonyms	503610-43-3; (2S,4R)-4-Hydroxy-2-[2-[4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonylamino)pyrimidin-5-yl]ethenyl]-3,4-dihydro-2H-pyran-6-one; N-Methyl-N-[4-(4-fluorophenyl)-6-isopropyl-5-[(1E)-2-[(2S,4R)-4-hydroxy-6-oxo-3,4-dihydro-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]methanesulfonamide; A complex pyrimidine sulfonamide derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring material that meets ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.