Description

4-Chlorocarbonyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, versatile chemical building block essential for advanced organic synthesis. This compound serves as a key protected intermediate, enabling the controlled introduction of the piperazine moiety into complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of piperazine-containing drug candidates, including potential antivirals, antidepressants, and antipsychotics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the piperazine scaffold imparts specific biological activity.
• Peptide Mimetics & PROTACs: Facilitates the construction of peptide-like structures and proteolysis-targeting chimeras (PROTACs) for drug discovery.
• Material Science Research: Employed in the synthesis of specialized polymers and ligands for catalytic or sensing applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and reference standards.

Basic Information

Product Name	4-Chlorocarbonyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	59878-28-3
Molecular Formula	C10H17ClN2O3
Molecular Weight	248.71 g/mol
Synonyms	1-Boc-4-(chlorocarbonyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(chloroformyl)piperazine; tert-Butyl 4-(chloroformyl)piperazine-1-carboxylate; 4-(Chloroformyl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; Piperazine-1-carboxylic acid tert-butyl ester, 4-chlorocarbonyl-; Boc-Piperazine-4-carbonyl Chloride; N-Boc-4-Piperazinecarbonyl Chloride
EINECS	Contact for details

Quality Control

Our 4-Chlorocarbonyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and ISO environments for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.