Description

Sulindac Sulfone is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) Sulindac. This compound is of significant interest in advanced pharmaceutical research and development, particularly in the study of drug metabolism and the synthesis of novel therapeutic agents. It serves as a critical building block for researchers and manufacturers in the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis and research of Sulindac and related anti-inflammatory compounds.
• Metabolite Reference Standard: Essential for analytical method development, pharmacokinetic studies, and bioanalytical testing in drug discovery.
• Biochemical Research: Used in studies investigating the mechanisms of action, metabolic pathways, and pharmacological profiles of NSAIDs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor or key intermediate in the development of new chemical entities.
• Quality Control & Regulatory Testing: Employed as a certified reference material (CRM) for impurity profiling and assay validation to meet regulatory standards (e.g., FDA, ICH).

Basic Information

Product Name	Sulindac Sulfone
CAS No.	59864-67-4
Molecular Formula	C20H17FO3S
Molecular Weight	356.41 g/mol
Synonyms	(Z)-5-Fluoro-2-methyl-1-[(4-methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; FGN-1; Sulindac Sulfoxide; (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; Sulindac sulfoxide; Z-5-Fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)indene-3-acetic acid; AHR-5850D; 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (Z)-
EINECS	Contact for details

Quality Control

Our Sulindac Sulfone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.